The Skin and Natural Cannabinoids–Topical and Transdermal Applications
The chemical constituents of the Cannabis plant known as cannabinoids have been extensively researched for their potential therapeutic benefits. The use of cannabinoids applied to the skin as a potential method for both skin-related benefits and systemic administration has attracted increasing interest in recent years. This review aims to present...
The Inheritance of Chemical Phenotype in Cannabis sativa L.
Our crosses were made between inbred Cannabis sativa plants with pure cannabidiol (CBD) and pure Δ-9-tetrahydrocannabinol (THC) chemotypes. All the plants belonging to the F1’s were analyzed by gas chromatography for cannabinoid composition and constantly found to have a mixed CBD-THC chemotype. Ten individual F1 plants were self-fertilized, and 10 inbred F2 offspring were...
Demystifying Cannabis: A Review of Its Pharmacology, Use in Pain, and Safety Concerns
The uses for cannabis and its synthetic derivatives continue to grow, as the regulatory status surrounding the drug becomes more legalized. Cannabis is composed of many chemical compounds, called cannabinoids, of which cannabidiol and 9-tetrahydrocannabinol have been studied for medicinal uses. As a modality for treatment of pain, cannabis may...
Terpenes in Cannabis sativa – From plant genome to humans
Cannabis sativa (cannabis) produces a resin that is valued for its psychoactive and medicinal properties. Despite being the foundation of a multi-billion dollar global industry, scientific knowledge and research on cannabis is lagging behind compared to other high-value crops. This is largely due to legal restrictions that have prevented many...
About Cannabis Terpenes
Terpenes are the primary constituents of essential oils and are responsible for the aroma characteristics of cannabis. Together with the cannabinoids, terpenes illustrate synergic and/or entourage effect and their interactions have only been speculated in for the last few decades.
Hundreds of terpenes are identified that allude to cannabis sensory attributes,...
CBD attenuates inflammatory impairment of intestinal cells expanding biomaterial-based therapeutic approaches
Cannabis-based biomaterials have the potential to deliver anti-inflammatory therapeutics specifically to desired cells, tissues, and organs, enhancing drug delivery and the effectiveness of anti-inflammatory treatment while minimizing toxicity.
As a major component of Cannabis, Cannabidiol (CBD) has gained major attention in recent years because of its potential therapeutic properties, e.g., for...
Prenatal cannabinoid exposure
Cannabinoid use in all populations is increasing as legalization across the United States continues. Concerningly, there is a lack of caution provided by medical providers to pregnant individuals as to the impact the use of cannabinoids could have on the developing fetus. Research continues in both the preclinical and clinical...
Nonpsychoactive Cannabinoids: Their Chemistry and Role against Oxidative Stress, Inflammation, and Cancer
In the last decades, a lot of attention has been paid to the compounds present in medicinal Cannabis sativa L., such as Δ9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD), and their effects on inflammation and cancer-related pain. The National Cancer Institute (NCI) currently recognizes medicinal C. sativa as an effective treatment for providing relief in a...
Phytochemistry of Cannabis sativa
Cannabis (Cannabis sativa, or hemp) and its constituents-in particular the cannabinoids-have been the focus of extensive chemical and biological research for almost half a century since the discovery of the chemical structure of its major active constituent, Δ9-tetrahydrocannabinol (Δ9-THC). The plant's behavioral and psychotropic effects are attributed to its content...
Adverse effects of cannabis
Cannabis, Cannabis sativa L., is used to produce a resin that contains high levels of cannabinoids, particularly delta9-tetrahydrocannabinol (THC), which are psychoactive substances. Although cannabis use is illegal in France and in many other countries, it is widely used for its relaxing or euphoric effects, especially by adolescents...
What is the difference between smoked and edible cannabis?
Smoked and edible cannabis are two different methods of consuming cannabis, and they have distinct differences in their effects, onset time, and duration.
The main difference between smoked and edible cannabis is the onset time and duration of effects. When smoked or vaporized, the effects of cannabis are felt almost immediately...
What is the legal status of hemp vs. marijuana?
Marijuana, also known as cannabis, is a plant that contains over 100 different compounds, including tetrahydrocannabinol (THC) and cannabidiol (CBD). The legal status of marijuana varies greatly across the world and has undergone significant changes in recent years.
At the federal level in the United States, marijuana remains a Schedule I...
What is the difference between THC and CBD?
Cannabidiol (CBD) and tetrahydrocannabinol (THC) are two of the most well-known compounds found in the cannabis plant. While both have similar chemical structures and are classified as cannabinoids, they have distinct differences in their effects on the body and mind.
One of the most significant differences between CBD and THC is...
How Cannabinoids (CBD, CBN & THC) Affect Sleep Quality
The importance of getting a good night’s rest cannot be overstated. Preliminary research published by the National Institute of Neurological Disorders suggests that while we sleep, the brain actively removes toxins that build up while we’re awake. Further, prolonged lack of sleep can lead to a variety of issues including high blood...